Supports Intuos3 (PTZ), Intuos2 (XD), Intuos1 (GD), Graphire2 (ET-A), Graphire (ET), CintiqPartner, Cintiq 21UX (DTZ-2100), 18SX, 15X and PL 500. Save the file to your computer and then double-click on it to launch the installer.
Notes:
1. For best results, uninstall the current driver on your system, restart, temporarily disable antivirus software & Vista's Windows Defender and install driver version 6.05-7. After completing the installation, re-enable your antivirus software & Vista's Windows Defender.
2. For concurrent use with a consumer pen tablet, install this driver as well as driver version 5.05 or later. These two drivers can now be added or removed independently of each other.
3. USB tablet required for Windows Vista (64 bit) and XP x64.
4. Serial tablets require connection through an on-board serial port. Connecting serial tablets through a USB-to-serial adapter leads to unpredictable results, and the Wacom driver does not support tablets that are connected through such adapters.

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Even after having fully packed features and heavy interface, this Wacom Intuos CTH 490 Driver is the best and flexible to operate and create the sketches on the desktop. System Requirement of Wacom Intuos CTH 490 Driver. To run Wacom Intuos CTH 490, if you are using Mac, then you should have OS X10.10. Wacom Intuos: CTL-4100, 4100WL, 6100, 6100WL. Uninstall the 6.3.40-2 driver and then install the 6.3.39-1 driver, which you can download here.

Wacom Intuos Driver Download Mac